Vitesse must get back to winning ways when they face AZ in the Eredivisie to avoid Ajax widening their lead at the top of the table.
Peter Bosz s side were top for seven consecutive weeks earlier in the season but draws in their last two matches have seen Ajax open up a two-point gap at the summit.
They face an AZ side who are slowly rebuilding their campaign after a poor run of form saw them slip from top to mid-table, with last weekend s 2-0 win over Groningen pushing them back up to sixth.
Vitesse, who are unbeaten 12 league matches, will be confident despite their recent dip given that AZ have not won back-to-back matches in the Eredivisie since November.
Ajax welcome Groningen to the Amsterdam Arena on Thursday and boast a proud record against the visitors, having never lost a home league match against them.
Frank de Boer s side were held by Utrecht last weekend, ending an eight-game winning streak that has seen them climb to the top of the table after 21 games.
Twente can move to within a point of Ajax if they win their game in hand, and face Heerenveen on Wednesday looking to preserve a nine-match unbeaten run.
Strugglers Roda JC welcome Feyenoord to the Parkstand Limburg Stadion on Tuesday hoping to collect a first win over Ronald Koeman s side since March 2011 and arrest a slump in form that has seen them drawn into the relegation battle.
Roda s relegation rivals Cambuur host PSV on Wednesday looking to apply further pressure on the under-fire Phillip Cocu, and Utrecht face PEC Zwolle in a mid-table battle a day later.
Bottom club ADO Den Haag face Heracles, NEC host NAC Breda , nd RKC Waalwijk visit Go Ahead Eagles.